Bone cancer, primary or secondary (metastatic) malignant tumor that affects the skeletal system of the body. Primary malignant bone tumors are sarcomas, ie tumors of the connective tissue of origin, they appear directly in the bones or joints. Metastatic tumors develop from cancer cells formed in other cancerous tissues and organs, and caught in the bones or joints, usually hematogenous (through blood).
The types and frequency of sarcomas.
Sarcomas develop from undergoing malignant degeneration of cells of the connective tissue that forms the skeleton. These tumors include osteosarcoma arising from the bone cell chondrosarcoma - of cartilage cells, malignant fibrosarcoma and fibrogistiotsitomy - from the cells of fibrous connective tissue, as well as lymphoma and Ewing's sarcoma of bone marrow origin. These sarcomas are composed of atypical spindle-shaped cells with a high rate of cell division. Carkomy differ in the nature of the product produced by them, for example, osteosarcoma produces sarcomatous, or unmineralized, bone.
The types and frequency of sarcomas.
Sarcomas develop from undergoing malignant degeneration of cells of the connective tissue that forms the skeleton. These tumors include osteosarcoma arising from the bone cell chondrosarcoma - of cartilage cells, malignant fibrosarcoma and fibrogistiotsitomy - from the cells of fibrous connective tissue, as well as lymphoma and Ewing's sarcoma of bone marrow origin. These sarcomas are composed of atypical spindle-shaped cells with a high rate of cell division. Carkomy differ in the nature of the product produced by them, for example, osteosarcoma produces sarcomatous, or unmineralized, bone.
The most common primary malignant bone tumors are osteosarcoma is. Their incidence is approximately 1:500 000, and in the U.S. each year 450-500 cases. These tumors occur more often in men than in women, and the median age of patients was 18 years for men and 17 for women.
Symptoms and diagnosis of osteosarcoma.
Classic signs and symptoms of osteosarcoma are determined by the fact that it is slow-growing tumor. Being painless on palpation, it is at night, a dull pain and discomfort. Hidden, imperceptible onset of the disease is often hampered early diagnosis. The diagnosis can be established by X-ray examination, which reveals structural changes in the bone closer to its end (in the metaphysis), and often sarcomatous bone tissue in the tumor itself. Radioisotope scanning of the skeleton, which is estimated bone uptake of the radioactive substance injected, in such cases reveals an active process of bone formation. CT scan can be seen thickened outer portion (cortex) layer of bone and soft tissue mass outside the bone. In order to assess the degree of tumor proliferation, resort to arteriography - X-rays of blood vessels with the use of dyes. Because osteosarcoma through the bloodstream ultimately give metastases to the lungs, is also carried out X-ray .
Symptoms and diagnosis of osteosarcoma.
Classic signs and symptoms of osteosarcoma are determined by the fact that it is slow-growing tumor. Being painless on palpation, it is at night, a dull pain and discomfort. Hidden, imperceptible onset of the disease is often hampered early diagnosis. The diagnosis can be established by X-ray examination, which reveals structural changes in the bone closer to its end (in the metaphysis), and often sarcomatous bone tissue in the tumor itself. Radioisotope scanning of the skeleton, which is estimated bone uptake of the radioactive substance injected, in such cases reveals an active process of bone formation. CT scan can be seen thickened outer portion (cortex) layer of bone and soft tissue mass outside the bone. In order to assess the degree of tumor proliferation, resort to arteriography - X-rays of blood vessels with the use of dyes. Because osteosarcoma through the bloodstream ultimately give metastases to the lungs, is also carried out X-ray .
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